KIBRA (WWC1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	WWC1 antibody was raised against an 18 amino acid peptide near the amino terminus of human WWC1.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	WWC1 antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 123 kDa; Observed: 110 kDa
Gene Name	WW and C2 domain containing 1
Database Link	NP_001155133 Entrez Gene 23286 Human UniProt ID Q8IX03
Background	The WW and C2 domain containing 1 (WWC1) protein, also known as KIBRA, possesses two WW domains and an internal C2-like domain (1). WWC1 was originally identified as a memory performance-associated protein in humans (2) and has recently been shown to be a novel regulator of the Hippo pathway (3). WWC1 is phosphorylated by the mitotic kinases Aurora-A and ?? (4), and in turn activates the Aurora kinases and is required for precise chromosome alignment during mitosis (5).
Synonyms	PACS-2; PACS1L
Reference Data

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