P2X7 (P2RX7) Rabbit Polyclonal Antibody
CAT#: TA349115
Rabbit Polyclonal Anti-P2RX7 Antibody
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CNY 5,808.00
Cited in 3 publications. |
CNY 4,840.00
CNY 300.00
CNY 1,430.00
Specifications
Product Data | |
Applications | IF, WB |
Recommend Dilution | WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | P2RX7 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human P2RX7. |
Formulation | PBS containing 0.02% sodium azide. |
Concentration | 1 mg/ml |
Purification | P2RX7 antibody is affinity chromatography purified via peptide column. |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Predicted Protein Size | Predicted: 34, 47, 65 kDa; Observed: 54 kDa |
Gene Name | purinergic receptor P2X 7 |
Database Link | |
Background | The purinergic receptor P2X ligand-gated ion channel 7 (P2RX7) belongs to the family of purinoceptors for ATP (1). This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules (1,2). Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression (2). Recent studies have suggested that P2RX7 may play a key role in immune-mediated diseases such as rheumatoid arthritis (3) as well as neuropsychiatric disorders (4). |
Synonyms | P2X7 |
Reference Data | |
Protein Families | Druggable Genome, Ion Channels: ATP Receptors, Transmembrane |
Protein Pathways | Calcium signaling pathway, Neuroactive ligand-receptor interaction |
Citations (3)
The use of this Antibodies has been cited in the following citations: |
---|
Soybean lectin induces autophagy through P2RX7 dependent activation of NF-κB-ROS pathway to kill intracellular mycobacteria.
,null,
Biochimica et biophysica acta. General subjects
,PubMed ID 33253803
[P2RX7]
|
Calcimycin induced IL-12 production inhibits intracellular mycobacterial growth by enhancing autophagy.
,null,
Cytokine
,PubMed ID 30081297
[P2RX7]
|
Contribution of the Purinergic Receptor P2X7 to Development of Lung Immunopathology during Influenza Virus Infection
,null,
mBio
,PubMed ID 28351919
[P2RX7]
|
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