HES5 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	HES5 antibody was raised against a 19 amino acid peptide near the amino terminus of human HES5.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	HES5 antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 18 kDa; Observed: 17 kDa
Gene Name	hes family bHLH transcription factor 5
Database Link	NP_001010926 Entrez Gene 15208 MouseEntrez Gene 79225 RatEntrez Gene 388585 Human UniProt ID Q5TA89
Background	HES5 is a member of the HES family of transcriptional repressors, which are the mammalian homologs of the Drosophila Hairy and Enhancer of Split and contain basic Helix-loop-helix (bHLH) and Orange domains (1). The HES5 gene is a downstream target of the Notch signaling pathway and its expression is downregulated during human cartilage differentiation (2). HES5 can directly repress transcription of the E3 ligase FBW7-beta, creating a feedback loop that modulates Notch-mediated intestinal and neural stem cell fate decisions (3).
Synonyms	bHLHb38
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS
Protein Pathways	Notch signaling pathway

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