Jagged1 (JAG1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	JAG1 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human JAG1.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	JAG1 antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 134 kDa; Observed: 130 kDa
Gene Name	jagged 1
Database Link	NP_000205 Entrez Gene 16449 MouseEntrez Gene 29146 RatEntrez Gene 182 Human UniProt ID P78504
Background	The LIN-12/Notch family of transmembrane receptors plays a central role in development by regulating cell fate decisions (1). Ligands for Notch include JAG1, JAG2 and Delta. JAG1 is one of the DSL (Delta, Serrate, Lag2) transmembrane proteins that can activate Notch. It is involved in mammalian cardiovascular development and in cell-fate decisions during hematopoiesis (1,2). JAG1 is widely expressed in adult and fetal tissues and the mutation of the JAG1 gene is associated with Familial Tetrology of Fallot (3). JAG1 expression is associated with prostate cancer metastasis and is up-regulated in cervical squamous cell carcinoma (4,5).
Synonyms	AGS; AHD; AWS; CD339; HJ1; JAGL1
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Protein Pathways	Notch signaling pathway

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