Tau (MAPT) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	WB: 1 - 2 ug/mL, IHC: 5 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	TAU antibody was raised against a 19 amino acid peptide near the amino terminus of human TAU.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	TAU antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 83 kDa; Observed: 90 kDa
Gene Name	microtubule associated protein tau
Database Link	NP_058519 Entrez Gene 4137 Human UniProt ID P10636
Background	The microtubial-associated protein TAU (MAPT), more commonly known as TAU, is is normally a highly soluble protein found predominantly in neurons (1), but accumulations of highly phosphorylated tau protein aggregates are observed in several neurodegenerative diseases including Alzheimer?? disease, progressive supranuclear palsy, corticobasal degeneration, and frontotemporal lobar dementia. It was thought that these pathological tau aggregates were the toxic form of tau, but recent studies indicate that soluble and highly phosphorylated tau species are more closely associated with synaptic dysfunction and cell loss (2,3). Mutations in the TAU gene have also been associated with several of these neurodegenerative diseases (4).
Synonyms	CT1.4; MAGE-41; MAGE-X2; MAGE4; MAGE4A; MAGE4B
Reference Data

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