CTHRC1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	CTHRC1 antibody was raised against a 19 amino acid peptide near the amino terminus of human CTHRC1.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	CTHRC1 antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 27 kDa; Observed: 27 kDa
Gene Name	collagen triple helix repeat containing 1
Database Link	NP_612464 Entrez Gene 68588 MouseEntrez Gene 282836 RatEntrez Gene 115908 Human UniProt ID Q96CG8
Background	The Collagen triple helix repeat-containing protein (CTHRC1) is a glycosylated, secreted protein that is transiently expressed in the arterial wall in response to injury where it is thought to contribute to vascular remodeling by inhibiting collagen expression and deposition and promoting cell migration (1). CTHRC1 is highly expressed multiple human cancers, including pancreatic cancer where it plays a significant role in the progression and metastasis of the disease by regulating migration and adhesion of tumors cells (2). CTHRC1 overexpression can also be used as an independent prognostic marker in gastric cancer (3). Mutations at this locus have been associated with Barrett esophagus and esophageal adenocarcinoma (4).
Synonyms	collagen triple helix repeat containing 1
Reference Data
Protein Families	Secreted Protein

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