DNAJC13 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, WB
Recommend Dilution	DNAJC13 antibody can be used for detection of DNAJC13 by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. Antibody validated: Western Blot in mouse samples and Immunohistochemistry in human samples. All other applications and species not yet tested.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	DNAJC13 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human DNAJC13.
Specificity	DNAJC13 antibody is human and mouse reactive. At least two siforms of DNAJC13 are known to exist; this antibody will detect both isoforms. DNAJC13 antibody is predicted to not cross-react with other DNAJC family members.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	DNAJC13 antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 249 kDa; Observed: 249 kDa
Gene Name	DnaJ heat shock protein family (Hsp40) member C13
Database Link	NP_056083 Entrez Gene 235567 MouseEntrez Gene 23317 Human UniProt ID O75165
Background	DNAJC13, also known as receptor-mediated endocytosis 8 (RME8), is the human homolog to a DnaJ domain-containing protein originally identified in a screen for endocytic defects in C. elegans (1). It is thought to be a co-chaperone of Hsc70 which regulates protein conformation at membrane sites and plays a role in intracellular trafficking, co-localizing with markers of the endosomal system. Recent experiments have indicated that the DNAJC13 protein is involved in membrane trafficking through early endosomes but not through degradative organelles (2). DNAJC13 has been also been shown to regulate the intracellular trafficking of the epidermal growth factor receptor (3).
Synonyms	PARK21; RME8
Reference Data
Protein Families	Druggable Genome

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