TRPC3 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1 - 2 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	TRPC3 antibody was raised against a 19 amino acid peptide from near the carboxy terminus of human TRPC3.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	TRPC3 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 90, 93, 101 kDa; Observed: 93 kDa
Gene Name	transient receptor potential cation channel subfamily C member 3
Database Link	NP_001124170 Entrez Gene 22065 MouseEntrez Gene 60395 RatEntrez Gene 7222 Human UniProt ID Q13507
Background	The mammalian transient receptor potential (TRP) superfamily can be divided into three major families including the "canonical TRP" (TRPC) family. The seven members of this family share the activation through PLC-coupled receptors and have been suggested to be components of receptor-regulated cation channels in different cell types. Furthermore, the members of the TRPC3/6/7 subfamily can be activated by diacylglycerol analogs, suggesting a possible mechanism of activation of these channels by PLC-coupled receptors. TRPC3 encodes a Ca2+-permeant channel that is agonist-activated but not store-operated or directly receptor-activated. TRPC3 physically interacts with TRPC6 and TRPC7 and forms functional tetrameric channels.
Synonyms	SCA41; TRP3
Reference Data
Protein Families	Druggable Genome, Ion Channels: Transient receptor potential, Transmembrane

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