GAS 6 (GAS6) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1 - 2 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	GAS6 antibody was raised against a 19 amino acid peptide from near the amino terminus of human GAS6.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	GAS6 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 75 kDa; Observed: 75 kDa
Gene Name	growth arrest specific 6
Database Link	NP_000811 Entrez Gene 14456 MouseEntrez Gene 58935 RatEntrez Gene 2621 Human UniProt ID Q14393
Background	The growth arrest-specific 6 (GAS6) protein is a gamma-carboxyglutamic acid (Gla)-containing protein and a member of a family of plasma vitamin K-dependent proteins. GAS6 is involved in vascular homeostasis, cell proliferation, apoptosis, leukocyte migration, and platelet aggregation (1,2). GAS6 is the ligand for the type I transmembrane receptor tyrosine kinase receptors Tyro3, Axl, and Mer (3). This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker (4). Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia (2).
Synonyms	AXLLG; AXSF
Reference Data
Protein Families	Druggable Genome, Secreted Protein

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