PIP5K1 beta (PIP5K1B) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 50-200 Positive control: Human thyroid cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein of human PIP5K1B
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	phosphatidylinositol-4-phosphate 5-kinase type 1 beta
Database Link	NP_003549 Entrez Gene 18719 MouseEntrez Gene 309419 RatEntrez Gene 8395 Human UniProt ID O14986
Background	Phosphatidylinositol-4-phosphate-5-kinase (PIPK) synthesizes phosphatidylinositol-4,5-bisphosphate, which regulates various processes including cell proliferation, survival, membrane trafficking, and cytoskeletal organization. The PIPK family is divided into type I, type II and type III . Each type of the PIPK family phosphorylate distinct substrates and they contain an activation loop, which determines their enzymatic specificity and subcellular targeting . The phosphatidylinositol-4-phosphate-5-kinase type I consists of three members, PIPK I å, ∫, and ©, which are characterized by phosphorylating PI4P on the 5-hydroxyl . PIPK I å (designated PIPK I ∫ in mouse) is expressed in brain tissue . PIPK I ∫, designated PIPK I a in mouse, is also called STM7. PIPK I © has two variants produced by alternative splicing which are expressed in lung, brain, and kidneys.
Synonyms	MSS4; STM7
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Endocytosis, Fc gamma R-mediated phagocytosis, Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system, Regulation of actin cytoskeleton

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