Malignant T cell amplified sequence 1 (MCTS1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 200-1000 WB positive control: Jurkat and PC3 cells IHC: 100-300 Positive control: Human thyroid cancer Predicted cell location: Cytoplasm or Nucleus
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein of human MCTS1
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	21 kDa
Gene Name	malignant T-cell amplified sequence 1
Database Link	NP_054779 Entrez Gene 28985 Human UniProt ID Q9ULC4
Background	MCTS1 (malignant T cell amplified sequence 1), also known as MCT1, is a 181 amino acid protein that is ubiquitously expressed and localizes to the cytoplasm of cells. MCTS1 may play a role in cell cycle regulation by decreasing cell doubling time and by shortening the duration of G1 transit time and G1/S transition. The protein level of Cdk4 and Cdk6 kinases activity and cyclin D1 is enhanced by expression of MCTS1. As a translation enhancer, MCTS1 recruits DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile. MCTS1 promotes lymphoid tumor development and contributes to the pathogenesis and progression of breast cancer. MCTS1 positively regulates phosphorylation of ERK1 and ERK2.
Synonyms	MCT-1; MCT1
Reference Data
Protein Families	Druggable Genome

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