ARK5 (NUAK1) Rabbit Polyclonal Antibody

CAT#: TA350873S

Rabbit Polyclonal Anti-NUAK1 Antibody

Size: 25 ul 100 ul



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CNY 800.00

CNY 1,280.00


货期*
2周

规格
    • 25 ul

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经常一起买 (2)
beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
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Transient overexpression lysate of NUAK family, SNF1-like kinase, 1 (NUAK1)
    • 100 ug

CNY 4,840.00

Specifications

Product Data
Applications IHC
Recommend Dilution IHC: 100-300
Positive control: Human lung cancer
Predicted cell location: Cytoplasm
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide of human NUAK1
Formulation pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name NUAK family kinase 1
Background NUAK family SNF1-like kinase 1 also known as AMPK-related protein kinase 5 (ARK5) is an enzyme that in humans is encoded by the NUAK1 gene. Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1.
Synonyms ARK5
Reference Data
Protein Families Druggable Genome, Protein Kinase
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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