VPS4A Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: Human liver cancer tissue and 293T cells, A172, Hela and MCF7 cells IHC: 25-100 Positive control: Human liver cancer Predicted cell location: Cytoplasm and Cell membrane
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide of human VPS4A
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	49 kDa
Gene Name	vacuolar protein sorting 4 homolog A
Database Link	NP_037377 Entrez Gene 116733 MouseEntrez Gene 246772 RatEntrez Gene 27183 Human UniProt ID Q9UN37
Background	The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. The mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be really an yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 16; the gene for the other resides on chromosome 18.
Synonyms	SKD1; SKD1A; SKD2; VPS4; VPS4-1
Reference Data
Protein Pathways	Endocytosis

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