AP2 alpha (AP2A1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: A431, 231 and NIH/3T3 cell IHC: 25-100 Positive control: Human liver cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide of human AP2A1
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	108 kDa
Gene Name	adaptor related protein complex 2 alpha 1 subunit
Database Link	NP_570603 Entrez Gene 11771 MouseEntrez Gene 160 Human UniProt ID O95782
Background	This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP-2) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles. Alternative splicing of this gene results in two transcript variants encoding two different isoforms.
Synonyms	ADTAA; AP2-ALPHA; CLAPA1
Reference Data
Protein Pathways	Endocytosis, Huntington's disease

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