gamma Tubulin (TUBG1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	WB 1-5 µg/ml ELISA Not tested IP 2-5 µg/ml IHC 1-2 µg/ml FC Not tested
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide corresponding to aa 432-451 of human tubulin.
Formulation	This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
Purification	The Rabbit IgG is purified by Epitope Affinity Purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	50 kDa
Gene Name	tubulin gamma 1
Database Link	NP_001061 Entrez Gene 103733 MouseEntrez Gene 252921 RatEntrez Gene 7283 Human UniProt ID P23258
Background	Tubulin gamma, a member of the tubulin superfamily, is a ubiquitous and highly conserved protein within the microtubule organizing centre (MTOC). It is an essential structural protein for cell growth organizes microtubule arrays in the nucleus and cytoplasm. Tubulin gamma-depleted cells fail to form functional spindles and arrest during nuclear division. The phosphorylation of Tubulin gamma at Tyr445 plays a regulatory role in microtubule formation. The incidence rate for this phosphorylation event peaks during G1. The abundance of Gamma tubulin is less than 1% of the level of either alpha or beta tubulin. It shares approximately 28-32% identity with alpha tubulin from various organisms and 32-36% identity withbeta tubulins. The detection, localization and characterization of proteins involved in microtubule function is fundamental tothe understanding of mitosis, meiosis and the microtubule cytoskeleton. Antibodies reacting specifically with gamma tubulinserve as an essential tool in the detection of the presence and role of this molecule in various cellular settings. Gammatubulin 1 and Gamma tubulin 2 are different isoforms that are 97% homologous.
Synonyms	CDCBM4; GCP-1; TUBG; TUBGCP1
Reference Data
Protein Families	Druggable Genome

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