CD10 (MME) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB 0.1-1 µg/ml ELISA N/A IP N/A IHC 2-10 µg/ml FC Not tested
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to internal region of human CD10
Formulation	This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
Purification	The Rabbit IgG is purified by Epitope Affinity Purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	100 kDa
Gene Name	membrane metallo-endopeptidase
Database Link	NP_000893 Entrez Gene 4311 Human UniProt ID P08473
Background	CD10, also known as Common Acute Lymphocytic Leukemia Antigen (CALLA), is a 100-kDa type II transmembrane glycoprotein enzyme with neutral metalloendopeptidase activity which cleaves a variety of biologically active peptides hormones including glucagon, enkephalins, sybstance P, neurotensin, oxytocin and bradykinin. CD10 is largely expressed in ALL of lymphoblastic, Burkitt’s, and follicular germinal center lymphomas, as well as on CML of the surface of normal early lymphoid progenitor cells, immature B cells within adult bone marrow and germinal center B cells within lymphoid tissue. However, it is also found on a variety of normal tissues, such as breast myoepithelial cells, bile canaliculi, fibroblasts, with especially high expression on the brush border of kidney and gut epithelial cells. CD10 is present on leukemic cell of pre-B phenotype, which represenst 85% of cases of acute lymphocytic leukemia (ALL), thus it is an important cell surface marker in the diagnosis of human ALL.
Synonyms	CALLA; CD10; CMT2T; NEP; SCA43; SFE
Reference Data
Protein Families	Druggable Genome, Protease, Transmembrane
Protein Pathways	Alzheimer's disease, Hematopoietic cell lineage, Renin-angiotensin system

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