c Fos (FOS) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
Reactivity	Human, Rat, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide corresponding to N-term of c-Fos protein. This sequence is identical in human, mouse, rat abd bovine.
Formulation	This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
Purification	The Rabbit IgG is purified by Epitope Affinity Purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	~55 kDa
Gene Name	Fos proto-oncogene, AP-1 transcription factor subunit
Database Link	NP_005243 Entrez Gene 14281 MouseEntrez Gene 314322 RatEntrez Gene 2353 Human UniProt ID P01100
Background	The c-Fos proto-oncogene, an 55 kDa nuclear phosphor-protein, belongs to a family of transcription factors. It plays important roles in cell proliferation and differentiation. c-Fos is associated with the c-Jun protein, forming a stable c-Fos/c-Jun heterodimeric complex, this complex binds to the DNA promoter region which regulate transcription. Expression of the c-Fos gene is low in most normal adult tissues. However, high levels of expression have been detected in normal skin.
Synonyms	AP-1; C-FOS; p55
Reference Data
Protein Families	Druggable Genome, Transcription Factors
Protein Pathways	B cell receptor signaling pathway, Colorectal cancer, MAPK signaling pathway, Pathways in cancer, T cell receptor signaling pathway, Toll-like receptor signaling pathway

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