ER81 (ETV1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
Reactivity	Mouse, Human, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide corresponding to the C-terminus of human ER81 protein. This sequence is identical within human, rat, mouse, bovine, dog and chicken.
Formulation	This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
Purification	The Rabbit IgG is purified by Epitope Affinity Purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	56 kDa
Gene Name	ETS variant 1
Database Link	NP_004947 Entrez Gene 14009 MouseEntrez Gene 362733 RatEntrez Gene 2115 Human UniProt ID P50549
Background	The ETS transcription factors Ets2, ER81 and Elk1 belong to the Ets transcription factor family. ER81 (also designated ETV1) binds the motif 5'-CGGAA/T-3'. It is a prerequisite for normal development. An abnormal regulation contributes to neoplasia. ER81 is highly expressed in brain, testis, lung and heart. ER81 is also moderately expressed in spleen, pancreas, colon and small intestine. During development, ER81, PEA3 and ERM display unique expression patterns which suggest these transcriptional factors play an important role in organogenesis. ERK-1 activates ER81 transcriptional activity while MAPKAP kinase 2 inhibits ER81. ER81 also can be acetylated at N-terminus (Lys33 and Lys116).
Synonyms	ER81
Reference Data
Protein Families	ES Cell Differentiation/IPS, Transcription Factors

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