STAT4 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	Dot, WB
Recommend Dilution	WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC Not tested
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide surrounding to the epitope -KGYVP-- with phosphorylation sites at Tyr693 of STAT4 protein from human, mouse, rat, chicken dog and bovine origins.
Formulation	This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer.
Purification	The Rabbit IgG is purified by site-modified Epitope Affinity Purification.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	90 kDa
Gene Name	signal transducer and activator of transcription 4
Database Link	NP_001230764 Entrez Gene 20849 MouseEntrez Gene 6775 Human UniProt ID Q14765
Background	STAT proteins (Signal transducer and activator of transcription) belong to a family of cytoplasmic transcription factors that can be phosphorylated by a lignad binding to its cell surface receptor. Activation of STAT4 induces dimerization, nuclear translocation and DNA binding. STAT4 protein expression is restricted to the thymus, spleen and testis. Both tyrosine and serine residues on STAT4 become phosphorylated in response to IL-12 or IFN-a although serine phosphorylation is not required for DNA binding. STAT4 is activated in T-cells in response to the cytokine interleukin-12 (IL-12), and in NK cells by IL-2. STAT4-deficient mice display impaired IL-12 development of Th1 cells and enhanced development of Th2 cells.
Synonyms	SLEB11
Reference Data
Protein Families	Druggable Genome, Transcription Factors
Protein Pathways	Jak-STAT signaling pathway

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