CTLA4 Mouse Monoclonal Antibody [Clone ID: 2G10]
CAT#: TA355058
Mouse Monoclonal Anti-CTLA-4 Antibody [2G10]
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Specifications
Product Data | |
Clone Name | 2G10 |
Applications | ELISA, IF, IHC, WB |
Recommend Dilution | WB: 1-2µg/mL.IHC starting at 5µg/mL.IF start at 20µg/mL. |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | CTLA-4 antibody was raised against the extracellular domain of human CTLA-4. |
Formulation | CTLA-4 Antibody is supplied in PBS containing 0.02% sodium azide. |
Concentration | 1 mg/ml |
Purification | CTLA-4 Antibody is supplied as protein A purified IgG1. |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Predicted Protein Size | Predicted: 25 kDa; Observed: 32 kDa |
Gene Name | cytotoxic T-lymphocyte associated protein 4 |
Database Link | |
Background | The cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), also known as CD152, is a member of the immunoglobulin superfamily that is expressed by activated T cells and transmits an inhibitory signal to T cells (1,2). Both it and the homologous T-cell co-stimulatory protein CD28 bind to CD80 (B7-H1) and CD86 (B7-H2) on antigen-presenting cells (APCs) (3). Mutations in the CTLA-4 gene have been implicated in multiple autoimmune diseases (4). CTLA-4 also functions as an immune checkpoint protein, and anti- CTLA-4 antibodies have been successfully used in the treatment of cancer (5). |
Synonyms | CD; CD28; CD152; CELIAC3; CTLA-4; GRD4; GSE; ICOS; IDDM12 |
Note | CTLA-4 antibody can be used for detection of CTLA-4 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL. |
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