Phospholamban (PLN) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	Dot
Recommend Dilution	DB 1:500
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	The PLB Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T17 of human PLB.
Formulation	PBS with 0.09% (W/V) sodium azide
Purification	This antibody is purified through a protein A column, followed by peptide affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	6.1 kDa
Gene Name	phospholamban
Database Link	NP_002658 Entrez Gene 5350 Human UniProt ID P26678
Background	Phospholamban (PLB) is a 52 amino acid phosphoprotein which regulates the calcium pump of cardiac sarcoplasmic reticulum (SR). PLB is an oligomer of five identical subunits each having a cytoplasmic and transmembrane domain. The cytoplasmic domain (residues 1 to 25) contains the phosphorylation sites and is highly basic and readily cleaved by proteases; whereas the transmembrane domain (residues 25 to 52) is mostly hydrophobic, protease resistant and stabilizes the pentamer.
Synonyms	CMD1P; phospholamban; PLB
Reference Data
Protein Families	Transmembrane
Protein Pathways	Calcium signaling pathway, Dilated cardiomyopathy

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