LIGHT (TNFSF14) Mouse Monoclonal Antibody [Clone ID: 8D4]

CAT#: TA355115

Mouse Monoclonal Anti-LIGHT Antibody [8D4]



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CNY 6,861.00


货期*
5周

规格
    • 100 ug

经常一起买 (3)
beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
    • 30 ul

CNY 300.00
CNY 1,430.00


Recombinant protein of human tumor necrosis factor (ligand) superfamily, member 14 (TNFSF14), transcript variant 1, 100 µg
    • 100 ug

CNY 9,998.00


Transient overexpression lysate of tumor necrosis factor (ligand) superfamily, member 14 (TNFSF14), transcript variant 1
    • 100 ug

CNY 3,080.00

Specifications

Product Data
Clone Name 8D4
Applications FC, IF, IHC, WB
Recommend Dilution WB start at 0.5 - 1 ug/mL. IHC start at 2 - 5 ug/mL. IF start at 20 ug/mL.
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen LIGHT antibody was raised against the extracellular domain of human LIGHT.
Formulation LIGHT Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration 1 mg/ml
Purification LIGHT Antibody is supplied as protein A purified IgG2b.
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Predicted Protein Size Predicted: 26 kDa.
Gene Name tumor necrosis factor superfamily member 14
Background LIGHT Antibody: LIGHT, also known as Tumor Necrosis Factor Superfamily member 14 (TNFSF14), is a co-stimulatory molecule that can regulate T-cell activation and has recently been identified as an immune checkpoint protein. LIGHT binds to two different receptors, Herpes Virus Entry Mediator (HVEM) and Lymphotoxin beta Receptor (LTbR). While LIGHT binding to HVEM delivers a co-stimulatory signal to T cells , LIGHT binding to LTbR is critical for the formation of lymphoid structures which can stimulate T cell infiltration and activation of a tumor microenvironment, leading to rapid T cell-mediated tissue destruction. It has been shown that targeted delivery of LIGHT to tumors, thereby causing the T cell infiltration of the tumor, can enhance the response of the PD-1/PD-L1 checkpoint blockade anti-cancer therapy,suggesting that LIGHT may become a potent tool in anti-cancer treatment.
Synonyms CD258; HVEM-L; HVEML; LIGHT; LTg; TR2
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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