TIGIT Mouse Monoclonal Antibody [Clone ID: 4A12]

Specifications

Product Data
Clone Name	4A12
Applications	FC, IF, IHC, WB
Recommend Dilution	IHC start at 2 ug/mL. IF start at 1 ug/mL. FC start at 1 ug/mL. ICC start at 1 ug/mL. WB start at 1 ug/mL.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	TIGIT antibody was raised against the extracellular domain of human TIGIT
Formulation	TIGIT Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	TIGIT Antibody is supplied as protein A purified IgG1.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 26 kDa; Observed: 47 kDa
Gene Name	T-cell immunoreceptor with Ig and ITIM domains
Database Link	NP_776160 Entrez Gene 201633 Human UniProt ID Q495A1
Background	TIGIT Antibody: The T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the PVR (poliovirus receptor) family of immunoglobin proteins. It is expressed on several classes of T cells including follicular B helper T cells (TFH). TIGIT has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses .Similar to other immune checkpoint proteins such as PD-1, TIGIT is upregulated on exhausted T cells in chronic viral infections and cancer. Blockade of both TIGIT and PD-1 pathways leads to tumor rejection in mice suggesting that it may be of therapeutic use against cancer.
Synonyms	DKFZp667A205; FLJ39873; VSIG9; VSTM3; WUCAM
Reference Data

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