B7H3 (CD276) Mouse Monoclonal Antibody [Clone ID: 4H3]

Specifications

Product Data
Clone Name	4H3
Applications	ELISA, FC, IF, IHC, WB
Recommend Dilution	WB start at 0.25 ug/mL. IHC start at 2 ug/mL. ICC start at 1 ug/mL. IF start at 10 ug/mL. FC start at 1 ug/mL.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	B7-H3 antibody was raised against the extracellular domain of human B7-H3
Formulation	B7-H3 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	B7-H3 Antibody is supplied as protein A purified IgG1.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 57 kDa; Observed: 100 kDa
Gene Name	CD276 molecule
Database Link	NP_001019907 Entrez Gene 80381 Human UniProt ID Q5ZPR3
Background	CD276, also known as B7-H3, was initially identified as a member of the B7 family of proteins through its homology with previously identified B7 molecules.CD276 mRNA is widely expressed, but its protein expression is usually rather low. CD276 has been shown to play a role in both the costimulation as well as the coinhibition of T cell response.In a similar fashion, CD276 plays a critical role in the control of antitumor immune responses in some cases, while in others appears to mediate antitumor immunity. It thus joins other immune checkpoint proteins as a possible therapeutic target for at least a subset of cancers.
Synonyms	4Ig-B7-H3; B7-H3; B7H3
Reference Data

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.