BOB1 (POU2AF1) Mouse Monoclonal Antibody [Clone ID: TG14]

Specifications

Product Data
Clone Name	TG14
Applications	IHC
Recommend Dilution	1:20
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	A prokaryotic recombinant protein corresponding to 116 amino acids of the C-terminal region of the
Specificity	Human B cell specific octamer binding protein-1 (BOB-1).
Formulation	Liquid tissue culture supernatant containing 15 mM sodium azide as a preservative
Conjugation	Unconjugated
Storage Condition	Store at 2-8°C
Gene Name	POU class 2 associating factor 1
Database Link	Entrez Gene 5450 Human UniProt ID Q16633
Background	B cell specific octamer binding protein-1 (BOB-1), also known as OBF-1 and OCA-B, is a lymphocyte specific transcriptional coactivator protein. It interacts with OCT1 and OCT2 transcription factors and contributes to the transcriptional activity of octamer motifs. BOB-1 is used alongside OCT2 to differentiate between classic Hodgkin's lymphoma (both down regulated) and nodular lymphocyte predominant Hodgkin's lymphoma. BOB-1 has been reported to be detectable in all B cell populations found in reactive lymphoid tissues. The strongest expression being found in germinal center B cells and plasma cells. The expression of BOB-1 in B cell tumors has been reported to be variable. Used alongside OCT2 to differentiate between classic Hodgkin's lymphoma (both down regulated) and nodular lymphocyte predominant Hodgkin's lymphoma.
Synonyms	BOB-1; BOB1; OBF-1; OBF1; OCA-B; OCAB
Reference Data

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