CD163 Mouse Monoclonal Antibody [Clone ID: 10D6]

Specifications

Product Data
Clone Name	10D6
Applications	IHC
Recommend Dilution	1:200
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Prokaryotic recombinant protein corresponding to domains 1 to 4 of the N-terminal region of the CD163 molecule.
Specificity	Human CD163 antigen
Formulation	Liquid tissue culture supernatant containing sodium azide as a preservative
Conjugation	Unconjugated
Storage Condition	Store at 2-8°C
Gene Name	CD163 molecule
Database Link	Entrez Gene 9332 Human UniProt ID Q86VB7
Background	The CD163 molecule is a type I membrane protein also known as M130 antigen, Ber-Mac3, Ki-M8 or SM4. CD163 protein is restricted in its expression to the monocytic/macrophage lineage. It is reported to be present on all circulating monocytes and most tissue macrophages except those found in the mantle zone and germinal centers of lymphoid follicles, interdigitating reticulum cells and Langerhans cells. In addition, multi-nucleated cells within inflammatory lesions are reported not to express CD163 protein. The protein is upregulated by glucocorticoids and downregulated by the immunosuppressant cyclosporin A and by phorbol esters, while lipopolysaccharide, an inflammatory mediator, has no influence on expression. It has been proposed that a specific release mechanism of soluble CD163 antigen by human monocytes may play an important role in modulating inflammatory processes.
Synonyms	M130; MM130
Reference Data

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