Cytokeratin 7 (KRT7) Mouse Monoclonal Antibody [Clone ID: RN7]

Specifications

Product Data
Clone Name	RN7
Applications	IHC
Recommend Dilution	1:100
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Prokaryotic recombinant protein corresponding to part of the C-terminal region of the cytokeratin 7 intermediate filament molecule
Specificity	Human cytokeratin 7 intermediate filament protein.
Formulation	Liquid tissue culture supernatant containing sodium azide as a preservative
Conjugation	Unconjugated
Storage Condition	Store at 2-8°C
Gene Name	keratin 7
Database Link	Entrez Gene 3855 Human UniProt ID P08729
Background	Cytokeratins are intermediate filament proteins present in epithelial cells. They are expressed in a tissue-specific manner in normal organs and the tumors that arise from them. Cytokeratin 7 belongs to the neutral basic type B subfamily of cytokeratins. Its distribution is confined to glandular and transitional epithelia. Cytokeratin 7 is reported to be expressed in abundance in cultured bronchial and mesothelial cells but only at lower levels in cultured epidermal cells. The predicted amino acid sequence of this keratin has revealed a striking difference between this keratin and the type II keratins expressed in epidermal cells. Cytokeratin 7 has been reported in adenocarcinomas of the lung, breast, endometrium, ovary, thyroid as well as in carcinomas of the bladder and chromophobe renal cell carcinoma. Cytokeratin 7 and Cytokeratin 20 expression have been reported to show characteristic patterns on primary and metastatic lung and colorectal adenocarcinomas.
Synonyms	CK-7; CK7; Cytokeratin-7; K2C7; K7; Keratin-7; MGC3625; MGC129731; sarcolectin; SCL
Reference Data

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