MSH2 Mouse Monoclonal Antibody [Clone ID: 79H11]

Specifications

Product Data
Clone Name	79H11
Applications	IHC
Recommend Dilution	1:80
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Prokaryotic recombinant protein corresponding to a 304 amino acid region of the N-terminus of the human MSH2 molecule
Specificity	Human MSH2
Formulation	Liquid tissue culture supernatant containing sodium azide as a preservative
Conjugation	Unconjugated
Storage Condition	Store at 2-8°C
Gene Name	mutS homolog 2
Database Link	Entrez Gene 4436 Human UniProt ID P43246
Background	Human mismatch repair protein 2 (MSH2) is involved in the initial recognition of mismatched nucleotides during the post replication mismatch repair process. Therefore, the loss of MSH2 function leads to the accumulation of replication errors, which in turn may be responsible for the multiple mutations required for multistage carcinogenesis. MSH2 is reported to be expressed in the nuclei of cells from a variety of tissues including thyroid, heart, smooth muscle and the germinal centers of lymphoid follicles. In ileum and colon, MSH2 expression has been reported in the crypts, the cells which are undergoing rapid renewal. They are responsible for the continuous production of differentiated cells which migrate over 2 to 4 days before being sloughed into the lumen.
Synonyms	COCA1; FCC1; HNPCC; HNPCC1; LCFS2
Reference Data

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