delta Sarcoglycan (SGCD) Mouse Monoclonal Antibody [Clone ID: δSarc3/12C1]

Specifications

Product Data
Clone Name	δSarc3/12C1
Applications	IHC
Recommend Dilution	1:25–1:50 for 60 minutes at 25°C
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Synthetic peptide containing amino acids 1-19 at the N-terminus of the human delta-sarcoglycan sequence
Specificity	Human delta-sarcoglycan (35 kD). Does not react with delta-sarcoglycan in sections of mouse, rat, rabbit, dog, chicken, hamster or pig muscle. Other animal species not tested.
Formulation	Lyophilized tissue culture supernatant containing sodium azide as a preservative.
Reconstitution Method	The user is required to reconstitute the contents of the vial with the correct volume of sterile distilled water as indicated on the vial label
Conjugation	Unconjugated
Storage Condition	Store at 2-8°C
Gene Name	sarcoglycan delta
Database Link	Entrez Gene 6444 Human UniProt ID Q92629
Background	In normal skeletal muscle, dystrophin, the protein product of the gene which is defective in Duchenne and Becker muscular dystrophy, is attached to the muscle membrane via a complex of proteins (dystrophin-associated glycoproteins, DAGs). Dystrophin-deficient muscle shows a generalized reduction in DAG labeling. The expression of different members of the dystrophin glycoprotein complex is altered in several types of muscular dystrophy. For example, patients with LGMD2D have mutations in the gene for alpha-sarcoglycan, those with LGM2E have mutations in the beta-sarcoglycan gene, those with LGM2C have mutations in the gamma-sarcoglycan gene and those with LGM2F have mutations in the delta-sarcoglycan gene. As the sarcoglycans function together as a sub-complex, mutations in any one of the sarcoglycan genes usually results in variable expression for the whole group.
Synonyms	35DAG; CMD1L; DAGD; delta-sarcoglycan; LGMD2F; MGC22567; SG-delta; SGCDP; SGD
Reference Data

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