MLH1 Mouse Monoclonal Antibody [Clone ID: ES05]

Specifications

Product Data
Clone Name	ES05
Applications	IHC
Recommend Dilution	1:50
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Prokaryotic recombinant protein corresponding to 210 amino acids of human MLH1
Specificity	Human Mismatch Repair Protein (MLH1) molecule
Formulation	Liquid tissue culture supernatant containing 15 mM sodium azide as a preservative
Conjugation	Unconjugated
Storage Condition	Store at 2-8°C
Gene Name	mutL homolog 1
Database Link	Entrez Gene 4292 Human UniProt ID P40692
Background	MLH1, a mismatch repair protein involved in maintaining the integrity of genetic information, alongside MSH2, MSH6 and PMS2. Defects in DNA repair pathways have been linked to human carcinogenesis. Mutations in the MLH1 gene have been reported to be found in some forms of colon cancer, a subset of sporadic carcinomas and breast cancer. Loss of expression of MLH1 has also been reported in acute lymphoblastic leukemia, endometrial carcinoma, gastric carcinoma and ovarian carcinoma.
Synonyms	COCA2; FCC2; hMLH1; HNPCC; HNPCC2; MGC5172
Reference Data

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