MSH6 Mouse Monoclonal Antibody [Clone ID: PU29]

Specifications

Product Data
Clone Name	PU29
Applications	IHC
Recommend Dilution	1:100
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Prokaryotic recombinant protein corresponding to a 359 amino acid portion of the MSH6 human molecule
Specificity	Human mismatch repair protein 6
Formulation	Liquid tissue culture supernatant containing 15 mM sodium azide as a preservative
Conjugation	Unconjugated
Storage Condition	Store at 2-8°C
Gene Name	mutS homolog 6
Database Link	Entrez Gene 2956 Human UniProt ID P52701
Background	MSH6 is a 160 kD protein which is involved in DNA mismatch repair (MMR) and recombination pathways, when heterodimerized with MSH2. Defects in mismatch repair systems can cause mutations and can cause DNA microsatellite sequences to become unstable. Immunohistochemical studies have reported that MSH6 is strongly expressed in the nucleus of cells in normal colonic epithelium, especially in crypts. Expression is also found in lymphocytes. Studies have also shown that MSH6 is expressed in gastric carcinomas and endometrial carcinomas. However, sometimes expression can be lost in some endometrial carcinomas and colonic carcinomas with microsatellite instability.
Synonyms	GTBP; GTMBP; HNPCC5; HSAP; p160
Reference Data

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