Progesterone Receptor (PGR) Mouse Monoclonal Antibody [Clone ID: 16]

Specifications

Product Data
Clone Name	16
Applications	IHC
Recommend Dilution	1:100
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Prokaryotic recombinant protein corresponding to the N-terminal region of the A form of the human progesterone receptor
Specificity	Human progesterone receptor. A and B forms are detected in Western blotting procedures but only the A form is detected in immunohistochemical procedures. This may be the result of the epitope being inaccessible in the folded B form of the progesterone receptor protein.
Formulation	Liquid tissue culture supernatant containing sodium azide as a preservative
Conjugation	Unconjugated
Storage Condition	Store at 2-8°C
Gene Name	progesterone receptor
Database Link	Entrez Gene 5241 Human UniProt ID P06401
Background	The human progesterone receptor (PR) is expressed as two isoforms, PRA (94 kD) and PRB (114 kD), which function as ligand-activated transcription factors. These two isoforms are transcribed from distinct estrogen receptor (ER)-inducible promoters within a single copy PR gene. The PRA form is a truncated version of the PRB form, lacking the first 164 N-terminal amino acids. In humans, PRA acts as a transdominant repressor of the transcriptional activity of PRB, glucocorticoid receptor, ER, androgen receptor and mineralocorticoid receptor. PRB functions mainly as a transcriptional activator. PRB is expressed strongly in endometrial glandular and stromal nuclei in the proliferative phase of the menstrual cycle and weakly during the secretory phase and early pregnancy.
Synonyms	NR3C3; PR
Reference Data

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