Tyrosine Hydroxylase (TH) Mouse Monoclonal Antibody [Clone ID: 1B5]

Specifications

Product Data
Clone Name	1B5
Applications	IHC
Recommend Dilution	1:40
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Prokaryotic recombinant protein corresponding to a portion of the carboxyl terminal end of the mouse tyrosine hydroxylase molecule.
Specificity	Human tyrosine hydroxylase. Also reacts with mouse and rat tyrosine hydroxylase
Formulation	Liquid tissue culture supernatant containing sodium azide as a preservative
Conjugation	Unconjugated
Storage Condition	Store at 2-8°C
Gene Name	tyrosine hydroxylase
Database Link	Entrez Gene 7054 Human UniProt ID P07101
Background	Tyrosine hydroxylase is the first enzyme in catecholamine (CA) biosynthesis and catalyzes the conversion of L-tyrosine to L-DOPA. Tyrosine hydroxylase is reported to be expressed in all CA neurons. Despite the abundant data about the distribution of catecholaminergic neurons in a wide variety of species, data on their distribution in the human brain is less comprehensive. However, one such study has reported that tyrosine hydroxylase products in the substantia nigra were restricted to neural bodies, axons and dendrites. These in turn were restricted to the third decade of life and their number increased in this location with age. This finding may be related to ageing of melanin-pigmented neurons.
Synonyms	DYT5b; DYT14; TYH
Reference Data

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