Wilms Tumor Protein (WT1) Mouse Monoclonal Antibody [Clone ID: WT49]

Specifications

Product Data
Clone Name	WT49
Applications	IHC
Recommend Dilution	1:100
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	A prokaryotic recombinant protein containing 1–181 amino acids of the N-terminal of the Wilms’ Tumor protein
Specificity	Human Wilms’ Tumor WT1 gene product
Formulation	Liquid tissue culture supernatant containing sodium azide as a preservative
Conjugation	Unconjugated
Storage Condition	Store at 2-8°C
Gene Name	Wilms tumor 1
Database Link	Entrez Gene 7490 Human UniProt ID P19544
Background	Wilms' tumor protein (WT1) has a role in transcriptional regulation and is expressed in the kidney and a subset of hematopoietic cells. Alteration of transcription factor function is a common mechanism in oncogenesis. The WT1 protein contains a DNA binding domain and any deletions or point mutations of the WT1 gene which destroy this activity result in the development of the childhood nephroblastoma Wilms' tumor and Denys-Drash syndrome. The description of WT1 involvement in nephroblastoma is not clear.
Synonyms	AWT1; GUD; OTTHUMP00000037553; WAGR; WIT-2; WT33
Reference Data

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