Klrb1b Mouse Monoclonal Antibody [Clone ID: 28764]

Specifications

Product Data
Clone Name	28764
Applications	IHC
Recommend Dilution	Tested for immunohistochemistry (IHC); has been described to work in FACS. Approximate working dilution for IHC: Frozen sections: 0.1µg/ml (1:4000) Paraffin sections: does not react on routinely processed paraffin sections. Optimal dilutions should be determined by the end user. Suggested positive control: rat spleen.
Reactivity	Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified splenic NK cells from the LEW rat strain.
Specificity	Rat: NK cells and large granular lymphocytes Other species: not tested Epitope: The epitope has not been further characterized. Distribution: Isolated Cells: The antigen is described to be present on NK cells and large granular lymphocytes. Tissue Sections: The antigen is expressed on CD161 positive cells in various tissues, e.g. in rat spleen. There is a strong staining on cells in the red pulp, whereas there are only few cells with weak staining in the white pulp.
Formulation	Affinity purified, lyophilized Reconstitute by adding 0.5ml distilled water. This stock solution contains 0.4mg/ml IgG, phosphate buffered saline pH 7.2 (PBS), 5mg/ml bovine serum albumin (BSA) as a stabilizer and 0.09% sodium azide as a preservative.
Concentration	N/A
Conjugation	Unconjugated
Storage Condition	Original vial: 1 year at 4° - 8°C. Stock solution or aliquots thereof: 1 year at -20°C. Avoid repeated thawing and freezing.
Gene Name	killer cell lectin-like receptor subfamily B member 1B
Database Link	Entrez Gene 25192 Rat UniProt ID A4KWA1
Background	Monoclonal antibody 10-78 recognizes a 60kDa disulfide linked homodimer known as NKR- P1 or KLRB (Killer cell Lectin-like Receptor, subfamily B). This type II transmembrane glycoprotein of the C-type lectin superfamily is found on rat NK cells and large granular lymphocytes. Rat NKR-P1 comes in three highly related homologues (NKR-P1A, NKR-P1B and NKR-P1B*), similar to the three homologues found in mice (KLRB1A/NKR-P1A, KLRB1B/NKR-P1B and KLRB1C/NKR-P1C) while only one human homologue (KLRB1, NKR-P1A or CD161) has been described. NKR-P1 seems to play an important role in the cytotoxic function of natural killer cells.
Synonyms	Klrb1d; Ly55b; Ly55d; MGC163757; MGC163759; NKR-P1B; Nkr-p1b; NKR-P1D; Nkrp1-b; Nkrp1b; Nkrp1d
Reference Data

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.