Enkephalin (PENK) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA
Recommend Dilution	This antibody has been tested and validated in ELISA against Met- Enkephalin-Arg-Phe. Other applications like immunohistochemistry (IHC), FACS or Western Blot may work as well. Optimal dilutions should be determined by the end user.
Reactivity	Human, Mammalian
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide H-Tyr-Gly-Gly-Phe-Met-Arg-Phe-NH2 coupled to a carrier protein.
Formulation	Protein A affinity purified from antiserum, lyophilized, packaged under nitrogen. Reconstitute by adding 0.2ml distilled water. This stock solution contains 2mg/ml IgG, phosphate buffer saline pH 7.4 (PBS), and 0.02% (w/v) Thimerosal as a preservative.
Concentration	N/A
Conjugation	Unconjugated
Storage Condition	Original vial: at least one year at 4° - 8°C from date of delivery. Minimize repeated thawing and freezing of the antiserum by freezing aliquots at -20°C or below.
Gene Name	proenkephalin
Database Link	Entrez Gene 5179 Human UniProt ID P01210
Background	Met-Enkephalin is an endogenous opioid pentapeptide that has opioid effects of a relatively short duration. It is one of the two forms of enkephalin, the other being leu-enkephalin. The enkephalins are considered to be the primary endogenous ligands of the δ-opioid receptor, due to their high potency and selectivity for the site over the other endogenous opioids. Met- enkephalin is found mainly in the adrenal medulla and throughout the central nervous system (CNS). It is synthesized from proenkephalin via proteolytic cleavage. As a result, its cleavage generates: the met-enkephalin derivatives, the heptapeptide met-enkephalin-arg-phe (261– 267), and the octapeptide met-enkephalin-arg-gly-leu (186–193). This antibody was generated by immunization of rabbits with Methionine Enkephalin-Arg-Phe coupled to a carrier protein.
Synonyms	preproenkephalin; proenkephalin
Reference Data

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