FNDC3B Rabbit Polyclonal Antibody
CAT#: TA365196S
FNDC3B rabbit polyclonal antibody
Size: 100 ul
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CNY 800.00
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Specifications
Product Data | |
Applications | IHC |
Recommend Dilution | IHC: 30-150 Positive control: Human liver cancer Predicted cell location: Cytoplasm |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Full length fusion protein |
Formulation | pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification | Antigen affinity purification |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C. |
Gene Name | fibronectin type III domain containing 3B |
Database Link | |
Background | Adipogenesis, the process of transforming pre-adipocytes into mature fat cells, is of particular interest due to the role adipocytes play in obesity and type II diabetes. Adipocytes have been shown to affect a variety of functions, including hemostasis, angiogenesis and energy balance, by secreting hormones and bioactive peptides. The FNDC3B protein, also designated FAD104 (factor for adipocyte differentiation 104) or HCV NS5A-binding protein 37, is expressed during early adipogenesis. Belonging to the FNDC3 family of proteins, FNDC3B is a 1,204 amino acid protein that contains nine fibronectin type-III domains. FNDC3B-deficient mice die within one day of birth, suggesting that FNDC3B is crucial for postpartum survival. Mouse embryonic fibroblasts (MEFs) with loss of FNDC3B function displayed a reduction in stress fiber formation, indicating a role for FNDC3B in cell proliferation, adhesion, spreading and migration. |
Synonyms | DKFZp686D14170; DKFZp762K137; FAD104; FLJ23399; MGC10002; NS5ABP37; OTTHUMP00000210534; PRO4979; YVTM2421 |
Reference Data |
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