BDH2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 500-2000 WB positive control: 293T and A172 cell，Mouse kidney tissue lysates
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Full length fusion protein
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C.
Predicted Protein Size	27 kDa
Gene Name	3-hydroxybutyrate dehydrogenase, type 2
Database Link	Entrez Gene 56898 Human UniProt ID Q9BUT1
Background	DHRS6 (dehydrogenase/reductase SDR family member 6), also known as EFA6R, SDR15C1, UCPA-OR,UNQ6308 or BDH2, is a 245 amino acid cytoplasmic protein belonging to the short-chain dehydrogenases/reductases (SDR) family, an evolutionarily conserved family of oxidoreductases found in all forms of life. DHRS6 is a novel, cytosolic type II R-β-hydroxybutyrate dehydrogenase that exists as two alternatively spliced isoforms and may have an essential role as a nutrient or building block in cellular survival. Human DHRS6 and its vertebrate orthologs show high levels of sequence identities to bacterial hydroxybutyrate dehydrogenases. DHRS6 may play an important role in the peripheral utilization of 3-hydroxybutyrate and its cytoplasmic localization with its high ratio of oxidized NAD+, the NAD+ dependence and the kinetic parameters of DHRS6 make it suitable to convert high levels of circulating 3-hydroxybutyrate into acetoacetate.
Synonyms	DHRS6; EFA6R; FLJ13261; PRO20933; SDR15C1; UCPA-OR; UNQ6308
Reference Data

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