PSTPIP1 Rabbit Polyclonal Antibody

CAT#: TA366553S

PSTPIP1 rabbit polyclonal antibody

Size: 25 ul 100 ul



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CNY 800.00

CNY 1,280.00


货期*
2周

规格
    • 25 ul

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Specifications

Product Data
Applications IHC, WB
Recommend Dilution WB: 500-2000
WB positive control: K562 cell lysate
IHC: 200-300
Positive control: Human esophagus cancer
Predicted cell location: Cytoplasm
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Immunogen Fusion protein of human PSTPIP1
Formulation pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Condition Store at -20°C.
Predicted Protein Size 47 kDa
Gene Name proline-serine-threonine phosphatase interacting protein 1
Background This gene encodes a cytoskeletal protein that is highly expressed in hemopoietic tissues. This protein functions via its interaction with several different proteins involved in cytoskeletal organization and inflammatory processes. It binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, downregulating CD2-triggered adhesion. It binds PEST-type protein tyrosine phosphatases (PTP) and directs them to c-Abl kinase to mediate c-Abl dephosphorylation, thereby, regulating c-Abl activity. It also interacts with pyrin, which is found in association with the cytoskeleton in myeloid/monocytic cells and modulates immunoregulatory functions. Mutations in this gene are associated with PAPA (pyogenic sterile arthritis, pyoderma gangrenosum, and acne) syndrome. It is hypothesized that the disease-causing mutations compromise physiologic signaling necessary for the maintenance of a proper inflammatory response.
Synonyms CD2BP1; CD2BP1L; CD2BP1S; H-PIP; PAPAS; PSTPIP
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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