WAPL Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 20-100 Positive control: Human brain Predicted cell location: Nucleus or Cytoplasm
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide of human WAPL
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C.
Gene Name	WAPL cohesin release factor
Database Link	Entrez Gene 23063 Human UniProt ID Q7Z5K2
Background	WAPL (wings apart-like), also known as WAPAL or FOE, is a 1,190 amino acid protein that contains one WAPL domain and is expressed as two alternatively spliced isoforms, one of which localizes to the nucleus. Expressed in an isoform-dependent manner in heart, skeletal muscle and uterine cervix tumor tissue, WAPL is involved in sister-chromatid adhesion and overall cell growth, specifically playing a role in the development and metastasis of cancerous tissue. The gene encoding WAPL maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman’s syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria.
Reference Data

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