UNC45B Rabbit Polyclonal Antibody
CAT#: TA369792S
UNC45B rabbit polyclonal antibody
Size: 100 ul
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Specifications
Product Data | |
Applications | WB |
Recommend Dilution | WB: 500-2000 WB positive control: Mouse skeletal muscle tissue lysate |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Fusion protein of human UNC45B |
Formulation | pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification | Antigen affinity purification |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C. |
Predicted Protein Size | 104/95 kDa |
Gene Name | unc-45 myosin chaperone B |
Database Link | |
Background | This gene encodes a co-chaperone required for folding and accumulation of type II myosins. The protein consists of three tetratricopeptide repeat motifs at the N-terminus that form a complex with heat shock protein 90, a central region of unknown function that is conserved in all Unc-45 proteins, and a C-terminal Unc-45/Cro1/She4 domain. The protein is expressed at high levels in striated muscle, where its muscle myosin chaperone activity is dependent on heat shock protein 90 acting as a co-chaperone. A missense mutation in this gene has been associated with cataract development. Alternative splicing results in multiple transcript variants. |
Synonyms | CMYA4; FLJ38610; MGC119540; MGC119541; OTTHUMP00000163855; SMUNC45; UNC-45B; UNC45 |
Reference Data |
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