Calcium Sensing Receptor (CASR) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 50-300 Positive control: Human gastric cancer Predicted cell location: Cell membrane
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein of human CASR
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C.
Gene Name	calcium sensing receptor
Database Link	Entrez Gene 846 Human UniProt ID P41180
Background	The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism.
Synonyms	CAR; EIG8; FHH; FIH; GPRC2A; HHC; HHC1; MGC138441; NSHPT; PCAR1
Reference Data

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