Amyloid Precursor Protein (APP) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB,1:500 - 1:2000
Reactivity	Mouse, Rat
Modifications	Phospho T668
Host	Rabbit
Clonality	Polyclonal
Immunogen	A phospho specific peptide corresponding to residues surrounding T668 of human APP
Formulation	Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Concentration	lot specific
Purification	Affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20℃. Avoid freeze / thaw cycles.
Predicted Protein Size	34kDa/72-86kDa
Gene Name	amyloid beta precursor protein
Database Link	UniProt ID P05067
Background	This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
Synonyms	A4; AAA; ABPP; AD1; APPI; CTFgamma; CVAP; OTTHUMP00000096096; PN-II; PN2; PreA4
Reference Data

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