ATR Rabbit Polyclonal Antibody
CAT#: TA373854
Phospho-ATR-S428 Rabbit polyclonal Antibody
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CNY 2,900.00
货期*
2周
规格
经常一起买 (1)
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Specifications
Product Data | |
Applications | ICC/IF, IHC, WB |
Recommend Dilution | WB,1:500 - 1:2000 IHC,1:50 - 1:200 IF,1:50 - 1:200 |
Reactivity | Human, Mouse, Rat |
Modifications | Phospho S428 |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | A synthetic phosphorylated peptide around S428 of human ATR (NP_001175.2). |
Formulation | Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
Concentration | lot specific |
Purification | Affinity purification |
Conjugation | Unconjugated |
Storage Condition | Store at -20℃. Avoid freeze / thaw cycles. |
Predicted Protein Size | 294kDa/297kDa/301kDa |
Gene Name | ATR serine/threonine kinase |
Database Link | |
Background | The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist. |
Synonyms | FRP1; MEC1; SCKL; SCKL1 |
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