NEDD4 2 (NEDD4L) Rabbit Polyclonal Antibody

CAT#: TA379036

Phospho-NEDD4L-S448 Rabbit polyclonal Antibody



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CNY 2,900.00


货期*
2周

规格
    • 100 ul

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Specifications

Product Data
Applications WB
Recommend Dilution WB,1:500 - 1:2000
Reactivity Human, Mouse, Rat
Modifications Phospho S448
Host Rabbit
Clonality Polyclonal
Immunogen A synthetic phosphorylated peptide around S448 of human NEDD4L (NP_001138439.1).
Formulation Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Concentration lot specific
Purification Affinity purification
Conjugation Unconjugated
Storage Condition Store at -20℃. Avoid freeze / thaw cycles.
Predicted Protein Size 96-111kDa
Gene Name neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
Background This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Synonyms FLJ33870; hNedd4-2; KIAA0439; NEDD4-2; NEDD4.2; NEDL3; RSP5
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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