NPL4 (NPLOC4) Rabbit Polyclonal Antibody
CAT#: TA379258
NPLOC4 Rabbit polyclonal Antibody
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CNY 1,999.00
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货期*
2周
规格
经常一起买 (1)
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Specifications
Product Data | |
Applications | ICC/IF, WB |
Recommend Dilution | WB,1:1000 - 1:2000 IF,1:50 - 1:200 |
Reactivity | Human, Mouse, Rat |
Modifications | Unmodified |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human NPLOC4 (NP_060391.2). |
Formulation | Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
Concentration | lot specific |
Purification | Affinity purification |
Conjugation | Unconjugated |
Storage Condition | Store at -20℃. Avoid freeze / thaw cycles. |
Predicted Protein Size | 68kDa/69kDa |
Gene Name | NPL4 homolog, ubiquitin recognition factor |
Database Link | |
Background | The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity. Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I. |
Synonyms | FLJ20657; FLJ23742; KIAA1499; NPL4 |
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