RAF1 Rabbit Polyclonal Antibody

CAT#: TA380680

Phospho-Raf1-S259 Rabbit polyclonal Antibody



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CNY 2,900.00


货期*
2周

规格
    • 100 ul

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Specifications

Product Data
Applications IP, WB
Recommend Dilution WB,1:500 - 1:2000
IP,1:50 - 1:100
Reactivity Human
Modifications Phospho S259
Host Rabbit
Clonality Polyclonal
Immunogen A synthetic phosphorylated peptide around S259 of human Phospho-Raf1-S259 (NP_002871.1).
Formulation Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Concentration lot specific
Purification Affinity purification
Conjugation Unconjugated
Storage Condition Store at -20℃. Avoid freeze / thaw cycles.
Predicted Protein Size 73kDa/75kDa
Gene Name Raf-1 proto-oncogene, serine/threonine kinase
Background This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
Synonyms C-RAF; CRAF; NS5; RAF; Raf-1
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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