EMAP II (AIMP1) Rabbit Monoclonal Antibody [Clone ID: R01-5A9]

Specifications

Product Data
Clone Name	R01-5A9
Applications	WB
Recommend Dilution	WB: 1/1000
Reactivity	Human, Rat
Host	Rabbit
Clonality	Monoclonal
Immunogen	A synthetic peptide of human EMAP II
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 34 kDa; Observed MW: 34 kDa
Gene Name	aminoacyl tRNA synthetase complex interacting multifunctional protein 1
Database Link	Entrez Gene 9255 Human UniProt ID Q12904
Background	Swiss-Prot Acc.Q12904.Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7.
Synonyms	EMAP-2; EMAP2; EMAPII; p43; SCYE1
Reference Data

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