Caveolin 1 (CAV1) Rabbit Monoclonal Antibody [Clone ID: R01-9C9]

Specifications

Product Data
Clone Name	R01-9C9
Applications	IHC, WB
Recommend Dilution	WB: 1/1000-1/5000 IHC: 1/20
Reactivity	Human
Host	Rabbit
Clonality	Monoclonal
Immunogen	A synthetic peptide of human Caveolin-1
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 20 kDa; Observed MW: 20 kDa
Gene Name	caveolin 1
Database Link	Entrez Gene 857 Human UniProt ID Q03135
Background	Swiss-Prot Acc.Q03135.May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity . Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292). Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564).
Synonyms	BSCL3; CAV; CGL3; MSTP085; VIP21
Reference Data

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