HP1 gamma (CBX3) Rabbit Monoclonal Antibody [Clone ID: R02-8A2]

Specifications

Product Data
Clone Name	R02-8A2
Applications	IHC, IP, WB
Recommend Dilution	WB: 1/1000 IHC: 1/20-1/500 IP: 1/20
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Monoclonal
Immunogen	A synthetic peptide of mouse HP1 gamma
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 21 kDa; Observed MW: 21 kDa
Gene Name	chromobox 3
Database Link	Entrez Gene 11335 Human UniProt ID P23198
Background	Swiss-Prot Acc.P23198.Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Probably involved in the repression of many genes located in euchromatin, such as E2F1, MYC and CDC25A. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1 (PubMed:24413057). Mediates the recruitement of NIPBL to sites of DNA damage at double-strand breaks (DSBs) .
Synonyms	HECH; HP1-GAMMA; HP1Hs-gamma
Reference Data

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